Publications by authors named "C Morisset"
Fifty million people worldwide are affected by dementia, a heterogeneous neurodegenerative condition encompassing diseases such as Alzheimer's, vascular dementia, and Parkinson's. For them, cognitive decline is often the first marker of the pathology after irreversible brain damage has already occurred. Researchers now believe that structural and functional alterations of the brain vasculature could be early precursors of the diseases and are looking at how functional imaging could provide an early diagnosis years before irreversible clinical symptoms.
View Article and Find Full Text PDFObjective: This pragmatic, multicenter, open-label, randomized controlled trial (RCT) aimed to compare the effectiveness, safety, and cost-utility of a custom-made knee brace versus usual care over 1 year in medial knee osteoarthritis (OA).
Design: 120 patients with medial knee OA (VAS pain at rest >40/100), classified as Kellgren-Lawrence grade II-IV, were randomized into two groups: ODRA plus usual care (ODRA group) and usual care alone (UCA group). The primary effectiveness outcome was the change in VAS pain between M0 and M12.
Article Synopsis
- The current evaluation of hip osteoarthritis (OA) severity relies on subjective methods, and this study aims to explore the use of objective gait analysis, specifically pelvis-thorax coordination, to assess disease severity.
- The study included three groups: healthy subjects, severe hip OA patients (requiring surgery), and less severe hip OA patients (not requiring surgery), with evaluations conducted before and after surgery for the severe group.
- Findings showed that pelvis-thorax coordination in the coronal plane correlated with clinical severity, effectively distinguished healthy individuals from OA patients, and reliably differentiated between surgical and non-surgical OA patients, suggesting its potential as an objective outcome measure in clinical trials.
Lower-limb intersegmental coordination is a complex component of human walking. Aging may result in impairments of motor control and coordination contributing to the decline in mobility inducing loss of autonomy. Investigating intersegmental coordination could therefore provide insights into age-related changes in neuromuscular control of gait.
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