Publications by authors named "C Moreilhon"
Article Synopsis
- Acute myeloid leukemia (AML) is a type of blood cancer with unclear genetic risk factors, and this study explores its hereditary aspects through a meta-analysis.
- Researchers analyzed data from four studies involving 4,018 AML patients and 10,488 controls, finding significant genetic risk loci at two locations: 11q13.2 related to KMT5B and 6p21.32 related to HLA.
- The study enhances understanding of AML development and highlights the roles of genes linked to histone methylation and immune response.
Introduction: Therapy-related myelodysplastic syndrome and acute myeloid leukemia (t-MDS/AML) are defined as complications of previous cytotoxic therapy. Azacitidine (AZA), a hypomethylating agent, has showed activity in t-MDS/AML.
Objectives: We evaluated the clonal dynamics of AZA-treated t-MDS/AML.
Article Synopsis
- Myelodysplastic syndromes (MDS) are blood disorders linked to abnormal stem cells, with known risk factors including genetic mutations, therapies, aging, and chronic inflammation.
- A study identified 8 genetic locations associated with MDS in a European population, focusing on gene expression differences in bone marrow cells from MDS patients versus healthy controls.
- Higher expression of the gene PLA2G4A and lower expression of EYA2 were connected to worse survival rates, indicating their roles in MDS and suggesting that these genes impact immune regulation and could have clinical significance for treatment.
We report five chronic myeloid leukaemia (CML) patients in whom we identified and characterized undescribed BCR-ABL1 fusion transcripts. We investigated the precise features of the molecular rearrangements and the minimal residual disease follow-up for these five patients. Three resulted from new rearrangements between the BCR and ABL1 sequences (the breakpoints being located within BCR exon 13 in two cases and within BCR exon 18 in one case).
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