Publications by authors named "C Morehouse"
Do Caregivers Value the New Antiamyloid Treatments for Alzheimer's Disease More Than Home-Based Care?
Am J Geriatr Psychiatry
November 2024
Article Synopsis
- New FDA-approved antiamyloid medications Lecanemab and donanemab aim to modify Alzheimer's disease but raise concerns about their benefits versus risks and costs.
- An online survey of 392 caregivers revealed that most preferred home-based care over the new medications, with 56.9% favoring coverage for care.
- Caregivers who preferred medication tended to believe in its benefits and were more likely to be male, Hispanic, less educated, and less confident in their comprehension of the drugs.
Three years following the pandemic's emergence, COVID-19 has continued to affect much of the symptomatic population with widely varied respiratory complaints, fevers, numerous unexpected prodromal manifestations, and unknown long-term consequences. Scattered cases involving myopathies, rhabdomyolysis, and compartment syndrome have also been reported throughout the pandemic. Some similar cases have been attributed to systemic capillary leak syndrome (SCLS).
View Article and Find Full Text PDFArticle Synopsis
- Nirsevimab, a long-lasting monoclonal antibody developed to protect infants from RSV, shows great potential due to the high conservation of its binding site, although the emergence of escape variants needs further investigation from 2015 to 2021.
- The study analyzed RSV A and B prevalence across multiple global surveillance studies, revealing that most amino acids in the nirsevimab binding site remained stable, with only a notable polymorphism (Ile206Met:Gln209Arg) appearing in RSV B after 2016.
- The researchers found that nirsevimab effectively neutralizes various RSV strains, including some with binding-site changes, although certain RSV B variants showed reduced sensitivity to nirsevim
Behavioural flexibility is key to survival in a dynamic environmentWhile flexible, goal-directed behaviours are initially dependent on dorsomedial striatum, they become dependent on lateral striatum as behaviours become inflexible. Similarly, lesions of dopamine terminals in lateral striatum disrupt the development of inflexible habits. This work suggests that dopamine release in lateral striatum may drive inflexible behaviours, though few studies have investigated a causative role of subpopulations of striatal dopamine terminals in reversal learning, a measure of flexibility.
View Article and Find Full Text PDF