Publications by authors named "C Moran Tiesta"
Cardiovascular disease (CVD) is a global health crisis and a leading cause of morbidities and mortalities. Biomarkers whose evaluation would allow the detection of CVD at an early stage of development are actively sought. Biomarkers are objectively measured as indicators of health, disease, or response to an exposure or intervention, including therapeutic interventions.
View Article and Find Full Text PDFThe P53 protein, a cancer-associated transcriptional factor and tumor suppressor, houses a Zn ion in its DNA-binding domain (DBD), essential for sequence-specific DNA binding. However, common mutations at position 273, specifically from Arginine to Histidine and Cysteine, lead to a loss of function as a tumor suppressor, also called DNA contact mutations. The mutant (MT) P53 structure cannot stabilize DNA due to inadequate interaction.
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- The study investigates multi-drug resistant Acinetobacter baumannii, focusing on rare clinical isolates from India that produce the pigment pyomelanin.
- Researchers utilized methods like REP-PCR for genotyping and whole genome sequencing to analyze the genomic features of these isolates.
- Findings reveal that pyomelanin-producing strains are not only multidrug-resistant but also form strong biofilms with specific virulence and resistance genes, indicating advanced adaptability and potential health risks.
Article Synopsis
- Acute upper gastrointestinal bleeding (UGIB) has a significant mortality rate of around 10%, and while existing scoring systems exist, none effectively predict mortality outcomes.
- This study conducted in India compared the newly developed ABC score, based on age, blood tests, and comorbidities, against other pre-existing scoring systems to assess its effectiveness in predicting mortality.
- Results showed the ABC score had the highest accuracy (AUROC of 0.75) in predicting 30-day mortality, particularly showing better performance in patients with variceal bleeding compared to non-variceal bleeding.
Article Synopsis
- The study evaluated how palatial root length affects the effectiveness of lidocaine anesthesia in maxillary molar treatments, comparing open-mouth and closed-mouth techniques.
- Sixty patients' pre-operative pain levels were assessed, and they were randomly divided into two groups for the different techniques, with discomfort measured after the anesthesia was administered.
- Results indicated that the closed-mouth technique led to less discomfort and better outcomes than the open-mouth technique, particularly when the palatal root length exceeded 19 mm.