Capability and accuracy of usual statistical analyses in a real-world setting using a federated approach.

Methods: The objective of this project was to determine the capability of a federated analysis approach using DataSHIELD to maintain the level of results of a classical centralized analysis in a real-world setting. This research was carried out on an anonymous synthetic longitudinal real-world oncology cohort randomly splitted in three local databases, mimicking three healthcare organizations, stored in a federated data platform integrating DataSHIELD. No individual data transfer, statistics were calculated simultaneously but in parallel within each healthcare organization and only summary statistics (aggregates) were provided back to the federated data analyst.

[Not Available].

With the emergence of innovations and technological advancements – exemplified by telemedicine and more recently by the extremely rapid development of Generative Artificial Intelligence systems (Gen AI) like Large Language Models (LLM) such as ChatGPT – we are witnessing a progressive transformation of ancient Hippocratic medicine and the physician-patient relationship. These healthcare Gen AI, which carry inherently stakes, risks, opportunities, hopes, and concerns, justify an increased and reinforced ethical vigilance. These digital applications, multiplying, diversifying, and improving their performance day by day, tend to reshape the role and practices of healthcare professionals in their analytical and decision-making medical process.

Factors associated with extent of COVID-19 outbreaks: A prospective study in a large hospital network.

Background: The COVID-19 pandemic has generated numerous hospital outbreaks. This study aimed to identify factors related to the extent of nosocomial COVID-19 outbreaks in the largest French public health institution.

Methods: An observational study was conducted from July 2020 to September 2021.

Acute and repeated exposures of normal human bronchial epithelial (NHBE) cells culture to particles from a coloured pyrotechnic smoke.

Coloured pyrotechnic smokes are frequently used in the military field and occasionally by civilians, but their health hazards have been little studied. The main concern could rise from inhalation of smoke particles. Our previous study showed that acute exposure to particles from a red signalling smoke (RSS) induced an antioxidant and inflammatory responses in small airway epithelial cells.

Novel scores relevant to antimicrobial resistance and hospital-acquired infections developed with data from a multi-hospital consortium in the Parisian region of France.

Purpose: Indicators for comparing and understanding differences in antimicrobial resistance (AMR) and healthcare-associated infections (HAIs) for benchmarking are essential to identify priorities for hospitals.

Methods: This study measured the incidence of hospital-acquired or resistant Gram-negative bacilli bloodstream infections (GNB-BSIs) in a large public healthcare consortium in the Parisian region of France.

Results: Within each hospital, there was a strong positive correlation between the incidence of GNB-BSIs due to resistant GNB and the incidence of hospital-acquired GNB-BSIs.