Publications by authors named "C Molloy"
Article Synopsis
- The human IRGM gene is associated with inflammatory conditions like sepsis and Crohn's disease, where decreased expression can lead to increased inflammatory markers in the body.
- Prior research showed that changes in metabolism and mitochondrial functions are linked to increased inflammatory responses, but the exact mechanisms were unclear.
- New findings revealed that type I interferon (IFN) production in macrophages is crucial for heightened cytokine levels due to IRGM deficiency, and novel pathways affecting mitochondrial function contribute to this inflammatory response.
Introduction: At least 10% of hospital admissions in high-income countries, including Australia, are associated with patient safety incidents, which contribute to patient harm ('adverse events'). When a patient is seriously harmed, an investigation or review is undertaken to reduce the risk of further incidents occurring. Despite 20 years of investigations into adverse events in healthcare, few evaluations provide evidence of their quality and effectiveness in reducing preventable harm.
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- Autism is a common condition influenced by both single gene issues and multiple genes, and many autistic people need better healthcare that genomics can help provide.
- The European Autism GEnomics Registry (EAGER) aims to collect info about autistic people who have had their entire DNA sequenced to help with future research and trials.
- EAGER will involve 1,500 participants from 13 places in 8 countries who will share genetic samples and fill out surveys to help researchers understand the link between genetics and health.
Background: Keeping best practice guidelines up-to-date with rapidly emerging research evidence is challenging. 'Living guidelines' approaches enable continual incorporation of new research, assisting healthcare professionals to apply the latest evidence to their clinical practice. However, information about how living guidelines are developed, maintained and applied is limited.
View Article and Find Full Text PDFExercise-based cardiac rehabilitation for adults with heart failure.
Cochrane Database Syst Rev
March 2024
Article Synopsis
- People with heart failure face significant challenges including low exercise tolerance, poor quality of life, increased hospital admissions, and high healthcare costs; exercise-based cardiac rehabilitation (ExCR) has shown potential benefits in these areas according to a 2018 review.
- The objectives of the new review were to evaluate the effects of ExCR on mortality, hospital admissions, and health-related quality of life among adults with heart failure.
- The study included randomized controlled trials that compared ExCR interventions to no exercise control, focusing on patients with both heart failure with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF).