Publications by authors named "C Molinas"
Article Synopsis
- Prader-Willi syndrome (PWS) is a rare genetic condition linked to cognitive and behavioral issues, obesity, and sleep problems, which may also involve autonomic nervous system dysfunction.
- A study investigated heart rate variability and autonomic function during sleep and standing in children with PWS, comparing results with age-matched controls, revealing significant impairment in heart rate responses and high rates of sleep apnea among the PWS group.
- Findings suggest decreased vagal modulation and possible sympathetic dysfunction in PWS children, which could increase their cardiovascular risks.
Article Synopsis
- A study evaluated the impact of older adults (aged 75+) spending a night in emergency departments (ED) on their risk of in-hospital mortality, comparing those who were admitted to wards before midnight versus those who stayed in the ED until morning.
- Despite slightly higher in-hospital mortality rates for those in the ED (10.7%) compared to the ward group (9.5%), the differences were not statistically significant, indicating that staying overnight in the ED did not conclusively increase mortality risk.
- The findings suggest that while older patients may face potential risks when waiting in an ED overnight, especially in non-academic hospitals, overall, there was no evidence of longer hospital stays or higher mortality rates tied to this practice
Introduction: Prader-Willi syndrome (PWS) is characterized by a switch from failure to thrive to excessive weight gain and hyperphagia in early childhood. An elevated, more unfavorable ratio between acylated and unacylated ghrelin (AG/UAG ratio) might play a role in the underlying mechanisms of this switch. We aimed to assess the evolution of the appetite-regulating hormones acylated ghrelin (AG) and unacylated ghrelin (UAG) and the AG/UAG ratio and their association with the change in eating behavior in children with PWS, compared to healthy age-matched controls.
View Article and Find Full Text PDFBackground: This study aimed to test the effect of a new training programme on emotional competencies, named EMO-T, and to show the value of an integrative developmental approach. This approach postulates that the emotion regulation disturbances commonly observed in neurodevelopmental disorders are the consequence of potential disruptions in the prerequisite emotion skills. This integrative approach is particularly suitable in the case of complex and multidimensional disorders such as Prader-Willi syndrome (PWS), a rare genetic disease.
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- Pituitary stalk interruption syndrome (PSIS) is a rare pediatric condition that causes hormonal deficiencies and has a variety of physical traits, with obesity often being overlooked in previous studies.
- The study examined 69 individuals with PSIS, identifying 25 who were obese or overweight, and compared their characteristics to 44 who were not.
- Results showed that obese/overweight patients had a higher history of neonatal hypoglycemia and extrapituitary malformations, suggesting potential underlying hypothalamic issues that need further research, especially regarding related hormones like oxytocin and ghrelin.