Comprehensive histopathological analysis of gastric cancer in European and Latin America populations reveals differences in PDL1, HER2, p53 and MUC6 expression.

Introduction: Gastric cancer (GC) burden is currently evolving with regional differences associated with complex behavioural, environmental, and genetic risk factors. The LEGACy study is a Horizon 2020-funded multi-institutional research project conducted prospectively to provide comprehensive data on the tumour biological characteristics of gastroesophageal cancer from European and LATAM countries.

Material And Methods: Treatment-naïve advanced gastroesophageal adenocarcinoma patients were prospectively recruited in seven European and LATAM countries.

Relationship between initial motor variability and learning and adaptive ability. A systematic review.

Motor variability is an intrinsic feature of human beings that has been associated with the ability for learning and adaptation to specific tasks. The purpose of this review is to examine whether there is a possible direct relationship between individuals' initial variability in their ability for learning and adaptation in motor tasks. Eighteen articles examined the relationship between initial motor variability and the ability for learning or adaptation.

Axillary Surgery for Patients With Residual Isolated Tumor Cells (ypN0i+) After Neoadjuvant Systemic Therapy for Early Breast Cancer.

Journal Journal of Clinical Oncology.

Alcohol-Induced & Drug-Induced Deaths in Hawai'i During the COVID-19 Pandemic.

During the COVID-19 pandemic, there was a marked increase in alcohol and drug-induced deaths. In the US, there was a rapid increase in the rate of alcohol- and drug-induced deaths within the first year of the COVID-19 pandemic compared to pre-pandemic years. This study examines mortality data within Hawai'i to assess both alcohol and drug-induced mortality during the pandemic compared to the nation overall.

Political practitioners poorly predict which messages persuade the public.

Do political practitioners have good intuitions about how to persuade the public? Longstanding theories that political elites' messages have large effects on public opinion and the large sums spent to secure some practitioners' messaging advice suggest they should. However, findings regarding the surprising limits of expert forecasts in other domains suggest they may not. In this paper, we evaluate how well political practitioners can predict which messages are most persuasive.