Publications by authors named "C Miyake"
Background: Fatty liver disease or steatotic liver disease (SLD) affects 25% of the global population and has been associated with heart disease. However, there is a lack of postmortem studies in the context of sudden cardiac death (SCD).
Objectives: To investigate the relationship between SLD and SCD.
Article Synopsis
- Event monitors are increasingly used to assess arrhythmias in patients with congenital heart disease, with only 8.8% showing critical events upon evaluation.
- The study reviewed data from 2017 to 2020, finding that patients with complex congenital heart disease and cardiomyopathy were more likely to experience these critical events.
- A significant number (65%) of patients with identified critical events received treatment, and usage of event monitors rose by 52% in the study period.
Structure-activity optimization of ryanodine receptor modulators for the treatment of catecholaminergic polymorphic ventricular tachycardia.
Heart Rhythm
October 2024
Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmia disorder associated with lethal arrhythmias. Most CPVT cases are caused by inherited variants in the gene encoding ryanodine receptor type 2 (RYR2).
Objective: The goal of this study was to investigate the structure-activity relationship of tetracaine derivatives and to test a lead compound in a mouse model of CPVT.
We have previously suggested that in rice (Oryza sativa L.) leaves of different ages and N nutrition statuses, photosystems II and I (PSII and PSI, respectively) are regulated depending on N partitioning to Rubisco, which can determine the magnitude of unutilized light energy. The robustness of this mechanism was tested using Rubisco-antisense transgenic rice plants, in which reduced N partitioning to Rubisco markedly increases unutilized light energy.
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- Ogden Syndrome and related neurodevelopmental disorders exhibit a range of symptoms including intellectual disability, hypotonia, and seizures, but there is limited imaging data on their neuroanatomical issues.
- The study aims to analyze neuroimaging from 26 individuals with these syndromes to identify common anomalies and their progression over time, incorporating detailed medical and developmental histories.
- Results show that those with Ogden Syndrome had significantly more anatomical abnormalities compared to those with NAA15 related syndrome, and a correlation exists between the number of abnormalities and poorer functional scores on the Vineland 3 scale.