Publications by authors named "C Miralles"
Background & Aims: This study aims to assess the incidence and characteristics of all cancers, hepatocellular carcinoma (HCC), and extrahepatic cancers in patients with cirrhosis of various etiologies.
Methods: Prospective cohort study in patients with cirrhosis but no cancer, followed every 6-9 months through the HCC early detection program. Cancer incidence was compared with Spanish population data to calculate standardized incidence ratios (SIR), and cumulative incidence was calculated separately for cancer and competing events.
Background: Hepatic venous portal gradient (HVPG) measurement remains the gold standard for estimating portal pressure gradient (PPG). This study aimed to evaluate the correlation between endoscopic ultrasound (EUS)-guided PPG and HVPG in patients with chronic portal hypertension.
Methods: Patients with chronic portal hypertension in whom HVPG assessment was clinically indicated were invited to undergo transjugular HVPG and EUS-PPG with a 22-G needle in separate sessions for comparison.
Article Synopsis
- Chronic schistosomiasis is likely more common among African migrant women in countries where the disease isn't typically found.
- There is a pressing need for a reliable diagnostic method to accurately assess how widespread this condition is.
- Understanding the clinical presentation of female genital schistosomiasis in this group is crucial for effective treatment and management.
Article Synopsis
- Cyclin-dependent kinase inhibitor 1A (Cip1/Waf1/CDKN1A/p21) primarily helps to control the cell cycle by inducing cell cycle arrest through inhibition of cyclin-dependent kinases (CDKs).
- Research has revealed that p21 is also involved in apoptosis, DNA damage response, and regulating stem cell fate, showing its dual role as both an oncogene and a tumor suppressor in different contexts.
- The review discusses clinical data on cancer patients and explores therapeutic strategies targeting CDKN1A/p21, highlighting its significance in cancer-related processes like cell proliferation, cancer stem cell renewal, and resistance to chemotherapy.
Anal squamous cell carcinoma (SCC) is not a common disease in the general population, although its incidence is higher in people living with human immunodeficiency virus (PLWH). Anal SCC is caused by human papillomavirus (HPV) infection and arises from premalignant lesions termed squamous intraepithelial lesions (SILs). SIL surveillance programs are based on the early detection and treatment of SILs, especially those with a higher risk of transforming into cancer.
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