Publications by authors named "C Milandri"
Background: Many gastric cancer patients in Western countries are diagnosed as metastatic with a median overall survival of less than twelve months using standard chemotherapy. Innovative treatments, like targeted therapy or immunotherapy, have recently proved to ameliorate prognosis, but a general agreement on managing oligometastatic disease has yet to be achieved. An international multi-disciplinary workshop was held in Bertinoro, Italy, in November 2022 to verify whether achieving a consensus on at least some topics was possible.
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- Interest in metastatic gastric cancer is rising, with the META-GASTRO registry aiming to gather clinical data on oligometastatic patients to guide multimodal treatment, including surgery.
- The study analyzed data from 383 patients, identifying oligometastatic cases through two definitions: quantitative/anatomical (specific site metastases) and dynamic (percentage based on site), finding relevant statistical significance.
- The results indicated that 30% of patients fit the quantitative definition and 16% the dynamic definition, with outcomes for conversion therapy similar to those who had surgery after initial chemotherapy.
Article Synopsis
- The Italian Research Group for Gastric Cancer created a database to assess how a practical approach influences stage IV gastric cancer management and patient outcomes.
- Data from 383 patients collected between 2018 and September 2022 showed increased use of laparoscopic techniques and a significant difference in surgical treatment strategies compared to past practices.
- The study found that while different metastatic sites didn't significantly affect survival rates, having multiple sites did worsen survival, indicating that better diagnosis and staging can improve outcomes for patients eligible for curative surgery.
Liquid biopsy is mainly used to identify tumor cells in pulmonary neoplasms. It is more often used in research than in clinical practice. The BL-MOL-AR study aims to investigate the efficacy of next-generation sequencing (NGS) and clinical interpretation of the circulating free DNA (cfDNA) levels.
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