Publications by authors named "C Miguel"
Disrupted feeding and fasting cycles as well as chronic high fat diet (HFD)-induced obesity are associated with cardiovascular disease risk factors. We designed studies that determined whether two weeks of time-restricted feeding (TRF) intervention in mice fed a chronic HFD would reduce cardiovascular disease risk factors. Mice were fed a normal diet (ND; 10% fat) ad libitum or HFD (45% fat) for 18 weeks ad libitum to establish diet-induced obesity.
View Article and Find Full Text PDFExcess dietary salt and salt-sensitivity contribute to cardiovascular disease. Distinct T cell phenotypic responses to high salt and hypertension as well as influences from environmental cues are not well understood. The aryl hydrocarbon receptor (AhR) is activated by dietary ligands, promoting T cell and systemic homeostasis.
View Article and Find Full Text PDFBackground: Extracorporeal photopheresis (ECP) product characteristics are not well established. The aim of this study was to compare mononuclear cells (MNCs) collection using the new Amicus blue (AB) In-line ECP system to our standard Off-line ECP system using the Optia apheresis device and the MacoGenic G2 inactivation system (OM).
Study Design And Methods: We assessed the ECP products and procedure parameters, patient characteristics, and adverse events for both AB and OM systems in paired patients.
Adult B-cell acute lymphoblastic leukemia (B-ALL) is characterized by genetic heterogeneity and a high relapse rate, affecting over 40% of adults. However, the mechanisms leading to relapse in adults are poorly understood. Forty-four adult B-ALL patients were studied at both diagnosis and relapse by next-generation sequencing (NGS).
View Article and Find Full Text PDFArticle Synopsis
- Cognitive-behavioral therapy (CBT) is identified as the most researched treatment for eating disorders, with a focus on its efficacy in clinical outcomes.
- A new meta-analysis included 36 trials involving 2,809 participants, highlighting CBT's effectiveness compared to control conditions, especially for binge eating disorder and bulimia nervosa.
- While the overall effect size for CBT was significant, indicating its benefits, a notable portion of patients still did not achieve sufficient improvement, suggesting the need for further research and alternative treatments.