Structure and function of the lysine methyltransferase SETD2 in cancer: From histones to cytoskeleton.

SETD2 is known to be the unique histone methyltransferase responsible for the trimethylation of the lysine 36 of histone H3 thus generating H3K36me3. This epigenetic mark is critical for transcriptional activation and elongation, DNA repair, mRNA splicing, and DNA methylation. Recurrent SETD2-inactivating mutations and altered H3K36me3 levels are found in cancer at high frequency and numerous studies indicate that SETD2 acts as a tumor suppressor.

Radiation Detectors and Sensors in Medical Imaging.

Medical imaging instrumentation design and construction is based on radiation sources and radiation detectors/sensors. This review focuses on the detectors and sensors of medical imaging systems. These systems are subdivided into various categories depending on their structure, the type of radiation they capture, how the radiation is measured, how the images are formed, and the medical goals they serve.

Structural and enzymatic evidence for the methylation of the ACK1 tyrosine kinase by the histone lysine methyltransferase SETD2.

SETD2 (SET-domain containing protein 2) is a histone methyltransferase (HMT) of the SET family responsible for the trimethylation of K36 of histone H3, thus producing the epigenetic mark H3K36me3. Recent studies have shown that certain SET family HMTs, such as SMYD2, SMYD3 or SETDB1 can also methylate protein kinases and therefore be involved in signaling pathways. Here we provide structural and enzymatic evidence showing that SETD2 methylates the protein tyrosine kinase ACK1 in vitro.

A phantom based evaluation of the clinical imaging performance of electronic portal imaging devices.

Purpose: In this study an evaluation of the imaging performance of an electronic portal imaging device (EPID) is presented. The evaluation performed employing the QC-3V image quality phantom.

Methods: An EPID system of a 6 MV LINAC, was used to obtain images of a QC-3V EPID phantom.

A Novel Method for Developing Thin Resin Scintillator Screens and Application in an X-ray CMOS Imaging Sensor.

Scintillating screens for X-ray imaging applications are prepared with various methods. Among them, the classic sedimentation method presents certain weak points. In this context, a novel fabrication process was developed that offers simplicity, economy of resources and time, while the screens exhibit adequate durability and image quality performance.