Open-source cold and hot scientific sheet press for investigating polymer-based material properties.

To produce samples for both material testing and molded sheets/parts, this article details an open-source scientific cold and hot press design. It consists of two independent and modular upper and lower plate (929 cm) assemblies each containing four 125 W insulated steel strip heaters. The steel housing for these heaters is entirely modular and designed for ease of manufacture, assembly, and customization.

A Reduction in Mitophagy Is Associated with Glaucomatous Neurodegeneration in Rodent Models of Glaucoma.

Glaucoma is a heterogenous group of optic neuropathies characterized by the degeneration of optic nerve axons and the progressive loss of retinal ganglion cells (RGCs), which could ultimately lead to vision loss. Elevated intraocular pressure (IOP) is a major risk factor in the development of glaucoma, and reducing IOP remains the main therapeutic strategy. Endothelin-1 (ET-1), a potent vasoactive peptide, has been shown to produce neurodegenerative effects in animal models of glaucoma.

Real-World Safety and Efficiency of Treating Symptomatic Varicose Veins with Endovenous Closure of Great, Small, and Anterior Accessory Veins Using Cyanoacrylate Glue (VenaSeal™): A Single-surgeon Multicenter Retrospective Study.

Background: Treatment of symptomatic varicose veins has changed dramatically in the last few years with guidelines now recommending endovenous surgery as first-line intervention. Previously, this was achieved by laser or radiofrequency ablation of the target vein, requiring infiltration of tumescent anesthesia to reduce the risks of thermal damage to surrounding tissue. Endovenous cyanoacrylate injection (VenaSeal™) is a nonthermal, nontumescent endovenous closure technique, increasing patient comfort and is readily performed under local anesthesia only and thus is a feasible technique for in-room treatment.

Understanding Early Treatment Response in Brief CBT for Nonunderweight Eating Disorders: A Mixed Methods Study.

Objective: Early change in eating disorder psychopathology is the most robust predictor of treatment outcomes in eating disorders. However, little is known about what predicts early change. Using mixed-methodology, this study explored predictors of early change in the first four sessions of 10-session cognitive behavioral therapy (CBT-T) for nonunderweight eating disorders.