Publications by authors named "C Mescoli"
Very early onset inflammatory bowel disease (VEO-IBD) is a clinical term referring to IBD-like symptomatology arising in children younger than 6 years. VEO-IBD may be due to polygenic etiology in "pure" IBD (Crohn disease-CD and ulcerative colitis-UC), or it may be caused by primary immunodeficiency underlined by monogenic disease. Primary immunodeficiency monogenic diseases have a Mendelian inheritance and affect the immune system with multiorgan morbidity and possible effects on the gastrointestinal system.
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- - The Banff Working Group on Liver Allograft Pathology convened in September 2022 with a diverse group of experts to discuss long-term health monitoring of liver transplants, focusing on noninvasive methods and optimizing immunosuppression.
- - The group considered revising the rejection classification scheme to better identify and communicate late T cell-mediated rejection patterns and related changes, like nodular regenerative hyperplasia.
- - They emphasized the need for personalized immunosuppression strategies based on individual patient needs and proposed incorporating interface hepatitis and fibrosis staging into the rejection classification, which will undergo further testing and discussion before the next conference.
Transplantation of an organ from a donor carries an unavoidable risk of tumor transmission. The need to extend the donor pool increases the use of organs from donors with malignancies and potential disease transmission is a constant tension influencing donor suitability decisions. Current classification systems for the assessment of donor malignancy transmission risk have evolved from reports of potential transmission events in recipients to national donation and transplant surveillance agencies.
View Article and Find Full Text PDFBackground: Recent studies showed that early surgery for Crohn's disease leads to a lower recurrence rate. However, the underlying mechanism is unknown.
Objective: The study aims to analyze the innate immunity microenvironment in ileal mucosa according to the duration of Crohn's disease.
Aims: Hirschsprung's-associated enterocolitis (HAEC) is the most severe complication of Hirschsprung disease (HD), and its pathogenesis is still unknown. Length of transition zone (TZ) interposed between aganglionic and normal bowel has been poorly explored as predictor for postoperative HAEC (post-HAEC). This study aimed to identify potential predictive factors for post-HAEC, with a particular focus on histopathological findings.
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