Publications by authors named "C Merry"
Predictors of Late Atrial Fibrillation Recurrence After Cardiac Surgery.
JACC Clin Electrophysiol
July 2024
Article Synopsis
- - This study investigated the predictors and timing of late atrial fibrillation (AF) recurrence in patients who underwent cardiac surgery, focusing on those without prior AF.
- - Out of 1,031 patients analyzed, 14% experienced late AF recurrence, with a significant link found between early postoperative AF (POAF) lasting more than 48 hours and later AF episodes.
- - The findings suggest that a longer POAF duration increases the risk of future AF, highlighting the need for further research on monitoring and treatment strategies for these patients.
Background: The aims of this study were to describe early and mid-term morbidity and mortality in octogenarian patients undergoing CABG, to determine if outcomes are comparable to younger patients undergoing the same procedure.
Methods: We conducted a retrospective analysis of the first 901 patients who underwent cardiac surgery at a large newly established tertiary hospital in Western Australia from February 2015 to September 2019. Inclusion criteria involved all patients undergoing coronary artery bypass grafting.
Perlecan (HSPG2), a heparan sulfate proteoglycan similar to agrin, is key for extracellular matrix (ECM) maturation and stabilization. Although crucial for cardiac development, its role remains elusive. We show that perlecan expression increases as cardiomyocytes mature in vivo and during human pluripotent stem cell differentiation to cardiomyocytes (hPSC-CMs).
View Article and Find Full Text PDFBackground: Cold static storage preservation of donor hearts for periods longer than 4 hours increases the risk of primary graft dysfunction (PGD). The aim of the study was to determine if hypothermic oxygenated perfusion (HOPE) could safely prolong the preservation time of donor hearts.
Methods: We conducted a nonrandomized, single arm, multicenter investigation of the effect of HOPE using the XVIVO Heart Preservation System on donor hearts with a projected preservation time of 6 to 8 hours on 30-day recipient survival and allograft function post-transplant.
Purpose: This 3D in vitro cancer model for propagation of patient-derived cells, using a synthetic self-assembling peptide gel, allows the formation of a fully characterised, tailorable tumour microenvironment. Unlike many existing 3D cancer models, the peptide gel is inert, apart from molecules and motifs deliberately added or produced by cells within the model.
Methods: Breast cancer patient-derived xenografts (PDXs) were disaggregated and embedded in a peptide hydrogel.