Publications by authors named "C Melissa Dobson"
Background: Individuals with disabilities experience a higher prevalence of sexually transmitted infections (STIs) compared to their counterparts without disabilities; however, there is limited data on whether they are screened for STIs at the same rate. The aim of this study was to determine whether adolescents and young adults with disabilities undergo routine screening for STIs at lower rates than individuals without disabilities.
Methods: We performed a retrospective cohort study of female patients aged 16-21 years who were seen between July 2021 and August 2023 by pediatrics, internal medicine/pediatrics, or family medicine at a single institution.
Background: Minimally invasive cheilectomy is becoming a more prominent surgical approach in the management of mild to moderate hallux rigidus. This systematic review aims to analyze and present the current literature on patient-reported outcomes following minimally invasive (MIS) cheilectomy for mild to moderate hallux rigidus.
Methods: PubMed, Cochrane Central Register of Controlled Trials, and Scopus databases were searched in April 2024.
Article Synopsis
- Filopodia, microspikes, and cytonemes are structures in cells that help sense the environment and transport various materials across tissues, built mainly from bundles of actin filaments.
- The study discovered monoclonal antibodies that can elongate filopodia-like structures by targeting a specific part of actin filaments known as the D-loop.
- By preventing actin disassembly, these antibodies provide insights into how the length of filopodia is regulated, suggesting that keeping the actin filament D-loop in an open state promotes longer structures.
Article Synopsis
- Tumor-infiltrating-lymphocyte (TIL) therapy can leverage the body's own T cells to fight tumors but has lengthy production processes that may reduce effectiveness.
- Researchers introduced a method using retroviral vectors paired with peptide-major histocompatibility complexes (pMHC) to deliver genes specifically to CD8 T cells, aiming to enhance their anti-tumor functions.
- The study showed that these pMHC-targeted viral vectors succeeded in activating and expanding effective anti-tumor T cells in mice, potentially simplifying the production of engineered cell therapies and improving survival rates in tumor-bearing models.
Purpose: Colorectal cancer (CRC) survivors report that diet and physical activity guidance from healthcare professionals following discharge from care is limited. Survivors seek advice from alternative sources. This study critically synthesised the English language diet and physical activity guidance available online for CRC survivors.
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