Publications by authors named "C Melero"

People with multiple sclerosis (PwMS) suffer cognitive and motor impairments that significantly impact their work life and daily functioning. Because virtual reality (VR) technologies have shown promise in the field of neurorehabilitation, in this study we developed a VR-based cognitive training program and assessed whether it could improve cognitive functioning in a cohort of PwMS (n = 33) and healthy control participants (n = 26). We observed that, in both groups of participants, repeated practice led to a day-by-day increase in correct responses and a progressive reduction in errors in the VR task.

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  • Human CD200R1 (hCD200R1) is an immune receptor found mainly on T cells and myeloid cells, and targeting it has shown promise in enhancing anti-tumor activity, particularly with a humanized antibody called 23ME-00610.
  • The study explores how 23ME-00610 blocks hCD200R1's immune checkpoint function by preventing its interaction with another molecule (CD200) through steric hindrance, while also creating a new antibody variant (23ME-00611) that binds effectively to the non-human equivalent (MfCD200R1) for preclinical studies.
  • This research not only sheds light on the molecular mechanics of hCD200R1 blockade but also
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Current CLL guidelines recommend a two parallel cultures assessment using TPA and IL2+DSP30 mitogens for complex karyotype (CK) detection. Studies comparing both mitogens for CK identification in the same cohort are lacking. We analyzed the global performance, CK detection, and concordance in the complexity assessment of two cytogenetic cultures from 255 CLL patients.

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Article Synopsis
  • Immune checkpoint inhibition (ICI) has changed cancer therapy, but only some patients experience long-term benefits, highlighting the need for new targets and treatments.* -
  • Researchers utilized the 23andMe database to find a genetic signature linking variations that affect both cancer and immune disease risks, discovering key genes like CD200 and CD200R1.* -
  • They developed a high-affinity antibody (23ME-00610) that inhibits the CD200:CD200R1 interaction, which enhances T-cell activity and reduces tumor growth in mouse models of melanoma.*
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