Publications by authors named "C Mele"
The history of an effective, specific and sensitive diagnostic test: the GHRH test in clinical practice.
Rev Endocr Metab Disord
December 2024
Growth hormone (GH) secretion is pulsatile, entropic, and nycthemeral and is mainly controlled by the hypothalamus through two neurohormones, the stimulating growth hormone releasing hormone (GHRH) and the inhibiting somatostatin. Shortly after its discovery and synthesis, GHRH was intensely investigated diagnostically to define GH secretion. The nascent enthusiasm for using GHRH as a single diagnostic tool to investigate GH deficiency (GHD) dropped down quickly due to a flawed reproducibility.
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- Biofilm formation in hospitals and public places poses a significant risk for spreading infections, making antimicrobial coatings essential for prevention.
- The study introduces a spray coating technique utilizing copper oxide nanoparticles (CuO NPs) in a titanium dioxide (TiO) sol, where CuO NPs provide antimicrobial properties and TiO serves as the binder.
- Coated polypropylene substrates showed dual benefits: strong antibacterial effects and superhydrophobic properties, with higher CuO NP concentration resulting in increased antibacterial activity and water resistance.
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- The study aims to develop a Preoperative Recurrence Score (PRS) to predict the risk of early recurrence in patients with perihilar cholangiocarcinoma (PCC) after surgery based on their preoperative imaging.
- Researchers collected data from 215 patients and found significant tumor characteristics (like size and vascular involvement) correlated with recurrence-free survival, successfully validating the PRS model across multiple patient cohorts.
- High PRS scores indicated a higher likelihood of recurrence, suggesting that surgery might not be beneficial for those patients, highlighting the need for careful consideration before proceeding to surgery.
Obesity has been recognized as a potential risk factor for the carcinogenesis of differentiated thyroid cancer (DTC). The aim of this observational study was to investigate the prognostic role of BMI in influencing DTC histopathological aggressiveness and the risk of tumor relapse. We enrolled 257 patients with DTC, consecutively admitted to our Institution between January 2016 and December 2023.
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