Publications by authors named "C Melander"
Article Synopsis
- Antimicrobial resistance (AMR) is severely limiting the effectiveness of antibiotics, especially against Gram-negative bacteria, making global health increasingly at risk.
- Researchers highlight that the rising resistance to colistin, a last-line antibiotic for treating multi-drug resistant infections, is particularly concerning.
- The study presents new adjuvants, including IMD-0354 and novel benzimidazole compounds, which effectively restore colistin sensitivity in resistant bacterial infections in mouse models, showing low toxicity and promising results in reducing bacterial load.
Article Synopsis
- Staphylococcus aureus can invade bone structures and cause infections like osteomyelitis, with the cell wall protein PBP4 being vital for this process.
- Deleting the pbp4 gene prevents the bacteria from invading bone networks and causing disease in mice.
- Research has identified a chemical, phenyl-urea 1, that targets PBP4, and further studies on related compounds have shown potential for better binding and effectiveness against antibiotic resistance.
Increasing antimicrobial resistance, coupled with the absence of new antibiotics, has led physicians to rely on colistin, a polymyxin with known nephrotoxicity, as the antibiotic of last resort for the treatment of infections caused by Gram-negative bacteria. One approach to increasing antibiotic efficacy and thereby reducing dosage is the use of small-molecule potentiators that augment antibiotic activity. We recently identified the aporphine alkaloid (±)-variabiline, which lowers the minimum inhibitory concentration of colistin in and .
View Article and Find Full Text PDFThe development of novel therapeutic approaches is crucial in the fight against multi-drug resistant (MDR) bacteria, particularly gram-negative species. Small molecule adjuvants that enhance the activity of otherwise gram-positive selective antibiotics against gram-negative bacteria have the potential to expand current treatment options. We have previously reported adjuvants based upon a 2-aminoimidazole (2-AI) scaffold that potentiate macrolide antibiotics against several gram-negative pathogens.
View Article and Find Full Text PDFExploring the meaning of a good life for older widows with extensive need of care: a qualitative in-home interview study.
Int J Qual Stud Health Well-being
December 2024
Introduction: Studies of older women's life transitions is rare but gains relevance as the aging population, with older women as the majority, expands.
Purpose: To explore the meaning of a good life for older widows with extensive home care needs.
Materials And Methods: Semi-structured interviews were carried out with eleven women, aged 80 and over (82-95 years, mean 90) residing at home with extensive care needs (≥4 daily sessions, averaging 2.