Publications by authors named "C Meda"
Intestinal Protozoa, Helminth Infection, and Associated Factors among Tuberculosis Patients and Nontuberculosis Persons in Bobo-Dioulasso City, Burkina Faso.
Am J Trop Med Hyg
December 2024
Article Synopsis
- The study analyzed the prevalence of co-infections with parasites in newly diagnosed pulmonary tuberculosis (TB) patients compared to non-TB participants in Bobo-Dioulasso from 2019 to 2021, finding a higher frequency of parasitic infections in the TB group (69.5% vs. 55.7%).
- Protozoal infections, especially by Entamoeba spp. and Cryptosporidium spp., were significantly more prevalent in TB+ patients, indicating a strong link between TB and certain types of parasites.
- Factors such as illiteracy, smoking, and inadequate hygiene practices (like not washing hands after defecation) were identified as potential contributors to parasite infections, suggesting a need for improved health
Background & Aims: The loss of ovarian functions defining menopause leads to profound metabolic changes and heightens the risk of developing metabolic dysfunction-associated steatotic liver disease (MASLD). Although estrogens primarily act on the female liver through estrogen receptor alpha (ERα), the specific contribution of impaired ERα signaling in triggering MASLD after menopause remains unclear.
Methods: To address this gap in knowledge, we compared the liver transcriptomes of sham-operated (SHAM) and ovariectomized (OVX) control and liver ERα knockout (LERKO) female mice by performing RNA-Seq analysis.
Immunological and Haematological Relevance of Helminths and Complex Coinfection among Newly Diagnosed Pulmonary Tuberculosis Patients from Bobo-Dioulasso, Burkina Faso.
Biomedicines
July 2024
The effect of helminthiasis on host immunity is a neglected area of research, particularly in tuberculosis (TB) infection. This study aimed to evaluate the effect of helminthiasis on immunological and haematological parameters in newly diagnosed TB patients in Bobo-Dioulasso. After all biological analyses, we formed three subpopulations: group 1 ( = 82), as control, were participants without helminthic or complex infection (-/Helm-), group 2 ( = 73) were TB patients without helminthic infection (+/Helm-), and group 3 ( = 22) were TB patients with helminthic infection (+/Helm+).
View Article and Find Full Text PDFTFEB and TFE3 belong to the MiT/TFE family of transcription factors that bind identical DNA responsive elements in the regulatory regions of target genes. They are involved in regulating lysosomal biogenesis, function, exocytosis, autophagy, and lipid catabolism. Precise control of TFEB and TFE3 activity is crucial for processes such as senescence, stress response, energy metabolism, and cellular catabolism.
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