Arrest in hospital: a study of in hospital cardiac arrest outcomes.

The effect of advances in cardiac arrest management over the last five decades on in-hospital cardiac arrest survival rates is not clear. Data on 212 arrests between January 2010 and May 2013 were retrospectively analyzed by means of an audit form based upon the Utstein template for in-hospital cardiac arrest, with a view to identifying significant associations between arrest characteristics and return of spontaneous circulation or survival to discharge. Significant associations were identified between return of spontaneous circulation and location (ward, 36 patients (38%) vs.

Analytical approach to determination of safety of milk ingredients from hyperimmunized cows.

Bovine milk-derived ingredients from cows hyperimmunized with a variety of antigens have been available experimentally or commercially for several decades. Although the safety of milk is rarely questioned, an assessment of ingredients derived from the milk of cows hyperimmunized with a proprietary bacterin (S100) was made to determine that these ingredients share the human food safety profile traditionally ascribed to regular milk. The critical elements in this determination are: (1) quantitative determination of the difference between S100 and regular dairy ingredients, (2) comparison of exposures resulting from proposed uses to background exposures already in the American diet, and (3) corroborative results of controlled clinical trials comparing safety outcomes from consumption of S100 with those of conventional dairy ingredients.

Detection of the mycophenolate-inhibited form of IMP dehydrogenase in vivo.

IMP dehydrogenase (IMPDH) is the rate-limiting enzyme for de novo GMP synthesis. Its activity is correlated with cell growth, and it is the target of a number of proven and experimental drug therapies including mycophenolic acid (MPA). MPA inhibits the enzyme by trapping a covalent nucleotide-enzyme intermediate.