Publications by authors named "C McCreery"
Background: Celiac disease (CeD) is an autoimmune condition characterized by an aberrant immune response triggered by the ingestion of gluten, which damages epithelial cells lining the small intestine. Small intestinal epithelial cells (sIECs) play key roles in the enzymatic digestion and absorption of nutrients, maintaining gut barrier integrity, and regulating immune response. Chronic inflammation and tissue damage associated with CeD disrupt the intricate network of metabolic processes in sIECs that support these functions, impairing their ability to perform their essential roles.
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- An 83-year-old woman suffering from severe aortic stenosis required a procedure called transcatheter aortic valve replacement due to her symptoms.
- Diagnostic tests revealed she also had widespread issues with her coronary arteries, known as 3-vessel coronary artery disease.
- This dual condition makes her case more complex, as both heart valve and artery issues need to be managed.
Uncontrolled arterial hypertension is a major global health issue. Catheter-based renal denervation has shown to lower blood pressure in sham-controlled trials and represents a device-based, complementary treatment option for hypertension. In this situation assessment, the authors, who are practicing experts in hypertension, nephrology, general practice and cardiology in the Republic of Ireland, discuss the current evidence base for the BP-lowering efficacy and safety of catheter-based renal denervation with different modalities.
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