Publications by authors named "C Maximo"
Urinary tract infections (UTIs) caused by resistant can lead to severe clinical complications and even death. An alternative treatment option for infected patients is using bacteriophages. In the present study, we isolated phage VB_KPM_KP1LMA (KP1LMA) from sewage water using a strain as a host.
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- Human genetic variation has helped identify key regulators of hemoglobin switching, notably BCL11A, leading to therapeutic advancements, but understanding of the broader regulatory mechanisms remains limited.
- A large genome-wide association study involving 28,279 individuals from 5 continents identified 178 significant genetic variants affecting fetal hemoglobin regulation.
- The research pinpointed BACH2 as a new regulator and clarified how certain genetic variations, including rare deletions, interact to influence fetal hemoglobin levels, paving the way for improved treatments for conditions like sickle cell disease and β-thalassemia.
Chronic kidney disease (CKD) has a significant impact on sickle cell disease (SCD) morbidity and mortality. Early identification of individuals at highest risk of developing CKD may allow therapeutic intervention to prevent worse outcomes. This study aimed to evaluate the prevalence and risk factors for reduced estimated glomerular filtration rate (eGFR) among adults with SCD in Brazil.
View Article and Find Full Text PDFObjective: To define the prevalence of leg ulcers and identify the clinical and laboratory factors associated with leg ulcers in adult participants.
Methods: The authors conducted a cross-sectional study of 1,109 patients who were 18 years or older with SS or Sβ0-thalassemia genotypes from a Brazilian cohort. Investigators assessed the prevalence of factors associated with leg ulcers from 2013 to 2017.
Manifestations of sickle cell disease (SCD) begin early in childhood and cause morbidity and decreased life expectancy. Hematopoietic stem cell transplantation (HSCT) is curative but associated with risk of mortality attributable to the transplant. This risk should be counterbalanced with SCD morbidity and mortality.
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