Early versus late infectious complications following chimeric antigen receptor-modified T-cell therapy.

Despite increasing utilization of CAR T-cell therapy, data are lacking regarding long term follow up and risk of infectious complications after the early period following CAR T-cell infusion. In this study, we sought to compare epidemiology and risk factors for early (≤ 3 months) and late (3 months to 1 year) infections. Data were retrospectively collected at six time points: pre-CAR T, day of infusion, and at 3, 6, 9, and 12 months post CAR-T infusion for all consecutive adult patients treated at our institution.

Novel replication-competent reporter-expressing Rift Valley fever viruses for molecular studies.

Unlabelled: Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic disease that causes severe disease in both domestic and wild ungulates and humans, making it a significant threat to livestock and public health. The RVFV genome consists of three single-stranded, negative-sense RNA segments differing in size: small (S), medium (M), and large (L). Segment S encodes the virus nucleoprotein N and the virulence-associated factor non-structural (NSs) protein in opposite orientations, separated by an intergenic region (IGR).

Antibiotic-Resistant from Market Meat in Peru.

Unconsidered microorganisms, such as may be often recovered from food samples. This study aimed to characterize seven recovered from traditional market chicken meat in Lima, Peru. Antimicrobial susceptibility to 18 antimicrobial agents as well as the presence of amino acid changes in fluoroquinolone targets, 10 mediated colistin resistance () genes and integrons were analyzed.

Deep reinforcement learning using deep-Q-network for Global Maximum Power Point tracking: Design and experiments in real photovoltaic systems.

This paper presents a methodology for integrating Deep Reinforcement Learning (DRL) using a Deep-Q-Network (DQN) agent into real-time experiments to achieve the Global Maximum Power Point (GMPP) of Photovoltaic (PV) systems under various environmental conditions. Conventional methods, such as the Perturb and Observe (P&O) algorithm, often become stuck at the Local Maximum Power Point (LMPP) and fail to reach the GMPP under Partial Shading Conditions (PSC). The main contribution of this work is the experimental validation of the DQN agent's implementation in a synchronous DC-DC Buck converter (step-down converter) un-der both uniform and PSC conditions.

A Phase III Randomized Trial of Integrated Genomics and Avatar Models for Personalized Treatment of Pancreatic Cancer: the AVATAR Trial.

Purpose: Pancreatic adenocarcinoma (PDAC) has limited treatment options. We compared the efficacy of comprehensive precision medicine against the conventional treatment in PDAC.

Methods: Phase III trial of advanced PDAC where patients were randomized (1:2) to a conventional treatment treated at physician's discretion (arm A), or to precision medicine (arm B).