Dietary Carrageenan Amplifies the Inflammatory Profile, but not Permeability, of Intestinal Epithelial Cells from Patients With Crohn's Disease.

Background: The consumption of ultra-processed foods has increased significantly worldwide and is associated with the rise in inflammatory bowel diseases. However, any causative factors and their underlying mechanisms are yet to be identified. This study aimed to further elucidate whether different types of the dietary emulsifier carrageenan (CGN) can alter the permeability and inflammatory state of the intestinal epithelium.

Tracking the journey: Gastrointestinal transit and intraluminal pH dynamics in aging populations using wireless motility capsule.

Introduction: Gastrointestinal (GI) changes may alter drug absorption, potentially impacting both efficacy and safety of oral pharmacotherapy. However, the GI physiology is rarely studied in the aging population. This study aimed to explore GI transit time and pH in geriatric inpatients and older adults, and compare these findings with those from young volunteers.

Development and User Experience Evaluation of an Experience Sampling-Based Dietary Assessment Method.

Background: Most technology-based dietary assessment methods use the same methodology as traditional dietary assessment methods resulting in similar limitations and biases. Experience sampling methodology (ESM) is a real-life real-time data-capturing method that is explored as an alternative methodology for dietary assessment to improve feasibility and data accuracy.

Objectives: This research aimed to develop and evaluate an experience sampling-based dietary assessment method (ESDAM) measuring habitual dietary intake.

Complications and Patient Satisfaction in Fully Edentulous Patients Treated with a Digital and Conventional Complete Denture, A Cross-Over Clinical Study.

Purpose: The objective of this clinical study was to evaluate comfort, satisfaction, chewing ability and complications with digital complete dentures (DCD) and conventional complete dentures (CCD).

Materials And Methods: For 16 edentulous patients, two sets of upper and lower dentures were fabricated by students in a university dental clinic. The impression for the DCD was done using indirect scanning of the cast.

Venom-derived peptides for breaking through the glass ceiling of drug development.

Venoms are complex mixtures produced by animals and consist of hundreds of components including small molecules, peptides, and enzymes selected for effectiveness and efficacy over millions of years of evolution. With the development of venomics, which combines genomics, transcriptomics, and proteomics to study animal venoms and their effects deeply, researchers have identified molecules that selectively and effectively act against membrane targets, such as ion channels and G protein-coupled receptors. Due to their remarkable physico-chemical properties, these molecules represent a credible source of new lead compounds.