Publications by authors named "C Matteo"
A response to "Substandard and disrespectful care during labour: Because words matter".
Eur J Obstet Gynecol Reprod Biol
December 2024
Background: Prevention and treatment of metastatic breast cancer (BC) is an unmet clinical need. The retinoic acid derivative fenretinide (FeR) was previously evaluated in Phase I-III clinical trials but, despite its excellent tolerability and antitumor activity in preclinical models, showed limited therapeutic efficacy due to poor bioavailability. We recently generated a new micellar formulation of FeR, Bionanofenretinide (Bio-nFeR) showing enhanced bioavailability, low toxicity, and strong antitumor efficacy on human lung cancer, colorectal cancer, and melanoma xenografts.
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- Chemoimmunotherapy (CIT) is an emerging cancer treatment that combines chemotherapy and immunotherapy to improve patient responses, but it faces challenges in delivering both drugs effectively to the right cells.
- A novel delivery strategy using different types of breakable organosilica nanocarriers allows for separate and timed delivery of a chemotherapy drug (doxorubicin) to cancer cells and an immunotherapy drug (resiquimod) to macrophages.
- The research indicates that using both nanocarriers together significantly reduces tumor cell viability compared to using either drug alone.
Article Synopsis
- Iron-sulfur (Fe-S) clusters are crucial for bacteria to respond to environmental changes and iron scarcity, with two primary biogenesis systems identified: ISC (housekeeping) and SUF (stress response).* -
- Most bacteria possess only one of these systems, typically SUF, but the human pathogen under study has only ISC, which is essential for its survival and adaptation under various conditions.* -
- This research highlights the different roles of ISC and SUF in bacterial fitness, revealing that bacteria with only ISC can better withstand oxidative stress and iron deprivation compared to those with only SUF.*
Vasostatin-1 restores autistic disorders in an idiopathic autism model (BTBR T+ Itpr3/J mice) by decreasing hippocampal neuroinflammation.
Prog Neuropsychopharmacol Biol Psychiatry
December 2024
Chromogranin A (CgA), a ∼ 49 kDa acidic secretory protein, is ubiquitously distributed in endocrine and neuroendocrine cells and neurons. As a propeptide, CgA is proteolytically cleaved to generate several peptides of biological importance, including pancreastatin (PST: hCgA), Vasostatin 1 (VS1: hCgA), and catestatin (CST: CgA ). VS1 represents the most conserved fragment of CgA.
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