Publications by authors named "C Massard"
Association of Lung Immune Prognostic Index (LIPI) with Disease Control Rate and Progression-Free Survival in Patients with Soft-Tissue Sarcoma Treated with Immunotherapy in Early-Phase Trials.
Cancers (Basel)
December 2024
Background: The efficacy of immunotherapies in soft-tissue sarcomas (STSs) is limited, and biomarkers of response are lacking. The lung immune prognostic index (LIPI) is a prognostic biomarker used with immunotherapy across cancer types. This study investigates the association of LIPI with the disease control rate (DCR) and progression-free survival (PFS) in patients with STS treated with immunotherapy versus other therapies in early-phase trials.
View Article and Find Full Text PDFGenetic diversity and phylogenetic relationships of Theileria equi inferred from heat shock protein 70 kDa gene sequences in Brazilian horses.
Vet Res Commun
November 2024
Article Synopsis
- Equine piroplasmosis, a disease caused by Babesia and Theileria parasites transmitted by ticks, poses significant clinical and economic threats globally, particularly to horses.
- This research focused on analyzing the heat shock protein 70 kDa (hsp70) gene sequences of Theileria equi from infected horses in Brazil, using methods like PCR and phylogenetic analysis to explore genetic relationships among parasites.
- Findings revealed two distinct genotypes of T. equi in Brazil, with hsp70 proving to be an effective molecular marker for distinguishing between closely related species and offering insights into the evolutionary history of these parasites.
A multiplex qPCR followed by high-resolution melting analysis for the detection of blood-feeding sources in Culex sp. mosquitoes.
Med Vet Entomol
November 2024
Culex species, such as Culex quinquefasciatus and Culex nigripalpus display a range of feeding habits and act as vectors for pathogens that can cause diseases in both humans and animals. Understanding their feeding habits is pivotal for enhancing disease prevention strategies. The present study introduces the application of two multiplex real-time PCR (qPCR) followed by high-resolution melting (HRM) as a cost-effective and time-efficient alternative.
View Article and Find Full Text PDFDetection, genetic diversity, and factors associated with infection by hemotropic mycoplasmas in rodent and marsupial populations in regions of the states of Rio de Janeiro and Parana, Brazil.
Microb Pathog
December 2024
Article Synopsis
- Hemotropic mycoplasmas, or hemoplasmas, are a group of bacteria found in various animal species and the study aimed to explore their presence and genetic diversity among small non-flying mammals in Brazil, focusing on environmental and animal factors affecting infection rates.* ! -
- Out of 257 sampled animals, 33.8% tested positive for hemotropic mycoplasma DNA, with the highest infection rates observed in the regions of Ponta Grossa and Cruz Machado and specifically in the rodent species Oligoryzomys.* ! -
- The study identified two phylogenetic clades of hemoplasmas and showed that males were significantly more likely to be infected than females, emphasizing the influence of