Publications by authors named "C Marzolini"
Background: Model-informed precision dosing (MIPD) combines population pharmacokinetic knowledge with therapeutic drug monitoring (TDM) to optimize dosage adjustment. It could improve target concentration attainment over empirical TDM, still widely practised for broad-spectrum antibiotics.
Objectives: To evaluate the respective performance of TDM and MIPD in achieving target piperacillin exposure.
Article Synopsis
- The study investigates how long-acting rilpivirine functions in real-life clinical settings, addressing gaps left by clinical trials on its pharmacokinetics in people with HIV.
- Researchers analyzed data from 238 patients to establish concentration curves and identify factors influencing drug exposure, finding differences in absorption rates between genders but minimal clinical impact.
- The findings suggest that around 50% of rilpivirine concentrations meet the optimal therapeutic threshold, indicating potential variability in treatment effectiveness among patients.
Background: Despite major advances in cancer treatment in the past years, there is a need to optimize chemotherapeutic drug dosing strategies to reduce toxicities, suboptimal responses, and the risk of relapse. Most cancer drugs have a narrow therapeutic index with substantial pharmacokinetics variability. Yet, current dosing approaches do not fully account for the complex pathophysiological characteristics of the patients.
View Article and Find Full Text PDFBackground: The World Health Organization is pushing to accelerate the study of new human immunodeficiency virus drugs in pregnant women. However, regulatory guidelines do not specify when to conduct pharmacokinetic studies in postpartum women. This knowledge gap carries the potential to jeopardize the outcomes and conclusions of clinical trials aiming to study the effect of pregnancy on drug exposure.
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