Publications by authors named "C Martinez-Rodriguez"
Article Synopsis
- - Microglial dysfunction is linked to Alzheimer's disease (AD), with a focus on a variant affecting the SIRPβ1 receptor that regulates the clearance of amyloid-β (Aβ).
- - The study found that a specific insertion in the SIRPβ1 gene alters protein function, increasing the risk of AD and affecting cognitive decline rates in patients with mild cognitive impairment.
- - Results suggest that this SIRPβ1 variant could influence microglial responses to Aβ and may serve as a potential target for treatment strategies that involve the TREM2-TYROBP pathway.
Article Synopsis
- The study investigates the role of Myb proteins in the encystation process of the parasite causing amebiasis, a leading cause of death from parasitic diseases.
- Researchers identified 48 MYB-domain-containing genes, classifying them into different types based on their structure, indicating their multifunctional roles in various cellular processes like transcription regulation and chromatin remodeling.
- The findings point to Myb proteins' involvement in regulating genes needed for encystation and other cellular functions, laying the groundwork for future research into treatment options for amebiasis.
The aim of this study was to analyze the prevalence of transmigrated canines in a Spanish population by evaluating their clinical and radiological characteristics. The descriptive observational study obtained 6840 orthopantomographs from all patients seeking dental care in the years 2017-21 via the Patient Reception Service and Dentistry Service at the Faculty of Dentistry at the Complutense University of Madrid and the Central Hospital of the Red Cross of Madrid (Spain). In total, 52 patients presented transmigrated canines, establishing a prevalence of 0.
View Article and Find Full Text PDFMycobacterium tuberculosis and human immunodeficiency virus-1 (HIV-1) syndemic interactions are a major global health concern. Despite the clinical significance of coinfection, our understanding of the cellular pathophysiology and the therapeutic pharmacodynamic impact of coinfection is limited. Here, we use single-round infectious HIV-1 pseudotyped viral particles expressing green fluorescent protein alongside M.
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