Publications by authors named "C Martinez-Losada"
Acute myeloid leukemia (AML) is a heterogeneous disease classified into three risk categories (favorable, intermediate and adverse) with significant differences in outcomes. Definitions of risk categories evolve overtime, incorporating advances in molecular knowledge of AML. In this study, we analyzed the impacts of evolving risk classifications in 130 consecutive AML patients in a single-center real-life experience.
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- - The study examines genetic changes in relapsed adult acute lymphoblastic leukemia (ALL), finding a high degree of genetic diversity without a clear relapse pattern, despite new treatments.
- - Analysis of samples from 31 adult patients indicated a trend of acquiring specific genetic deletions and an increase in genetic alterations from diagnosis to relapse, particularly involving genes like CDKN2A/B and PAX5.
- - The findings suggest that while the genetics of relapsed ALL is complex and varied, targeting specific deregulated pathways could enhance the effectiveness of current therapies for relapse cases.