An experimental investigation of oscillatory flow in the cerebral aqueduct.

This study aims at clarifying the relation between the oscillatory flow of cerebrospinal fluid (CSF) in the cerebral aqueduct, a narrow conduit connecting the third and fourth ventricles, and the corresponding interventricular pressure difference. Dimensional analysis is used in designing an anatomically correct scaled model of the aqueduct flow, with physical similarity maintained by adjusting the flow frequency and the properties of the working fluid. The time-varying pressure difference across the aqueduct corresponding to a given oscillatory flow rate is measured in parametric ranges covering the range of flow conditions commonly encountered in healthy subjects.

An In-Vitro Experimental Investigation of Oscillatory Flow in the Cerebral Aqueduct.

Background: The cerebrospinal fluid filling the ventricles of the brain moves with a cyclic velocity driven by the transmantle pressure, or instantaneous pressure difference between the lateral ventricles and the cerebral subarachnoid space. This dynamic phenomenon is of particular interest for understanding ventriculomegaly in cases of normal pressure hydrocephalus (NPH). The magnitude of the transmantle pressure is small, on the order of a few Pascals, thereby hindering direct measurements.

A one-dimensional model for the pulsating flow of cerebrospinal fluid in the spinal canal.

The monitoring of intracranial pressure (ICP) fluctuations, which is needed in the context of a number of neurological diseases, requires the insertion of pressure sensors, an invasive procedure with considerable risk factors. Intracranial pressure fluctuations drive the wave-like pulsatile motion of cerebrospinal fluid (CSF) along the compliant spinal canal. Systematically derived simplified models relating the ICP fluctuations with the resulting CSF flow rate can be useful in enabling indirect evaluations of the former from non-invasive magnetic resonance imaging (MRI) measurements of the latter.

Effect of Normal Breathing on the Movement of CSF in the Spinal Subarachnoid Space.

Background And Purpose: Forced respirations reportedly have an effect on CSF movement in the spinal canal. We studied respiratory-related CSF motion during normal respiration.

Materials And Methods: Six healthy subjects breathed at their normal rate with a visual guide to ensure an unchanging rhythm.

Drag reduction of three-dimensional bodies by base blowing with various gas densities.

This study reveals that injecting a light fluid of density ρ_{b} in the recirculating bubble of a bluff body at Re≈6.4×10^{4} has a greater drag reduction potential than blowing fluid of a density greater than or equal to that of the free stream ρ. It is found that the maximum drag reduction scales as (ρ_{b}/ρ)^{-1/6}.