Since December 2019, a new form of Severe Acute Respiratory Syndrome (SARS) has emerged worldwide, caused by SARS coronavirus 2 (SARS-CoV-2). This disease was called COVID-19 and was declared a pandemic by the World Health Organization in March 2020. Symptoms can vary from a common cold to severe pneumonia, hypoxemia, respiratory distress, and death.
View Article and Find Full Text PDFThe global resurgence of syphilis has created a potent stimulus for vaccine development. To identify potentially protective antibodies against Treponema pallidum (TPA), we used Pyrococcus furiosus thioredoxin (PfTrx) to display extracellular loops (ECLs) from three TPA outer membrane protein families (outer membrane factors for efflux pumps, eight-stranded β-barrels, and FadLs) to assess their reactivity with immune rabbit serum (IRS). We identified five immunodominant loops from the FadL orthologs TP0856, TP0858 and TP0865 by immunoblotting and ELISA.
View Article and Find Full Text PDFBackground: In 2019, a dengue outbreak involving Aedes albopictus occurred in a rural area of Espírito Santo, Brazil, motivating our study in Sooretama and Linhares.
Methods: We set traps to sample immature mosquito larvae at 40 sites, with weekly inspections from July 2022 to January 2023. Adult specimens were collected monthly at 19 sites, each collection lasting 15 min.