Redox-responsive polyurethane-polyurea nanoparticles targeting to aortic endothelium and atherosclerosis.

Aortic endothelial cell dysfunction is an early trigger of atherosclerosis, the major cause of the cardiovascular disease (CVD). Nanomedicines targeting vascular endothelium and lesions hold great promise as therapeutic solutions to vascular disorders. This study investigates the vascular delivery efficacy of polyurethane-polyurea nanocapsules (Puua-NCs) with pH-synchronized shell cationization and redox-triggered release.

Benefits of Well-Being Training in Healthy Older Adults.

Introduction: Several studies have shown that psychological well-being (PWB) can be promoted through positive psychological interventions (PPIs). Although these interventions have shown promising results in clinical settings, only a few studies have investigated their effectiveness in older adults, and they have rarely considered an active control group. In addition, generalisation effects of the PWB training to quality of life (QoL) and to untrained cognitive abilities have never been considered.

[Antologus and heterotopic splenic regeneration in rats].

Purpose: verify the cytological and histological aspects of the regeneration of fragments of autologous and heterotopic spleen implanted in peritoneal cavity and subcutaneous screen in Wistar albino rats.

Methods: forty four Wistar rats were assigned to one of two groups A (n=22) and B (n=22), which received their implants in subcutaneous screen and peritoneal cavity, respectively, under anesthesia. Those groups were redistributed in two other subgroups A1 (n=11) and B1 (n=11), which received one and four splenic fragments in the areas of study.

Cancer incidence in eighteen cities of the State of São Paulo, Brazil.

Objective: As in Brazil cancer registries are mostly based on large cities, there are no estimates per state or per region and information on the disease incidence in the vast in-land areas is very scarce. An incidence survey was conducted in 18 major cities of the state of São Paulo, excluding the capital, aiming to collect information about cancer incidence in the state of São Paulo.

Methods: Of the 18 cities in state of São Paulo included in the survey, all had available resources for cancer management.

[Hystological types and mortality for gastric cancer in São Paulo, Brazil].

The objective of this study was to analyze, according to Lauren's classification, the prevalence of a hystological type - intestinal or diffuse -, among gastric carcinomas. The authors reviewed 650 hystological sections from a Hospital in the City of São Paulo during a 30-year period, following the definitions of the above classification. After the 50's the intestinal type proved to be prevalent, reaching 62.