Publications by authors named "C Marie-Claire"
Background: Bipolar Disorder (BD) is associated with alterations of circadian rhythms of activity (CRA). Experimental research suggests that lithium (Li) modifies CRA, but this has been rarely explored in BD using actigraphy.
Methods: The sample comprised 88 euthymic BD-I cases with 3 weeks of actigraphy.
In bipolar disorders, abnormalities of sleep patterns and of circadian rhythms of activity are observed during mood episodes, but also persist during euthymia. Shared vulnerabilities between mood disorders and abnormalities of sleep patterns and circadian rhythms of activity have been suggested. This exploratory study investigated the association between polygenic risk scores for bipolar disorder and major depressive disorder, actigraphy estimates of sleep patterns, and circadian rhythms of activity in a sample of 62 euthymic individuals with bipolar disorder.
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- Individuals with bipolar disorders (BD) tend to have a shorter life expectancy, prompting the need for easily measurable markers of accelerated aging like BioAge, calculated from routine blood tests and physical exams.
- In a study of 2,220 outpatients with BD, results showed that a small percentage had significant BioAge Acceleration, which is linked to factors such as young age, male sex, being overweight, and sleep issues.
- Further research is needed to confirm these findings with different groups and explore whether improving factors like metabolic health and sleep could impact aging rates in individuals with BD.