Publications by authors named "C Mariat"
Article Synopsis
- The study aimed to enhance the Lund-Malmö GFR equation using rescaled cystatin C (r-LMR) and validate it against measured GFR in a large cohort of children and adults.
- Validation results showed that r-LMR performed with 86.2% accuracy in adults, outpacing the CAPA equation, indicating r-LMR is a reliable method for estimating GFR.
- The findings suggest that adapting the Lund-Malmö equation for rescaled cystatin C yields similar results to those based on rescaled creatinine, hinting at a reduced future need for specific GFR estimating equations.
Introduction: Membranous nephropathy can lead to end-stage kidney disease, for which kidney transplantation is the preferred therapy. However, the disease often relapses, which can impact allograft survival.
Methods: We conducted a prospective multicenter study in France involving 72 patients with membranous nephropathy who were awaiting and then underwent kidney transplantation.
Article Synopsis
- The study evaluates the effectiveness of machine learning (ML) techniques in predicting glomerular filtration rate (GFR) compared to the traditional EKFC equation, which measures kidney function.
- Using data from 19,629 patients across 13 cohorts, the researchers tested various ML methods, particularly focusing on factors like age, sex, and serum creatinine levels.
- Results indicated that the random forest (RF) method performed similarly to EKFC, with slight advantages for RF in younger patients, suggesting ML could enhance future GFR prediction methods.
Background: Creatinine-based equations are the most used to estimate glomerular filtration rate (eGFR). The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), the re-expressed Lund-Malmö Revised (r-LMR) and the European Kidney Function Consortium (EKFC) equations are the most validated. The EKFC and r-LMR equations have been suggested to have better performances in young adults, but this is debated.
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- - A survey conducted by the Transplantation Commission of the SFNDT gathered responses from 232 nephrologists across France, Switzerland, and Belgium regarding the management of immunosuppressants (IS) in patients experiencing kidney transplant failure (KTF) between March and June 2023.
- - Findings indicated that a significant number of nephrologists discontinued various IS treatments post-KTF, with 83% stopping antimetabolites, while 39.9% and 25.8% stopped calcineurin inhibitors (CNI) and corticosteroids, respectively. Some nephrologists, however, continued CNI (14%) and corticosteroids (19.1%) long-term, often influenced by patient factors like comor