Testosterone/cortisol ratio: gender effect and prediction of podium results in beach sprint master rowers.

Objective: The purpose of this study was to address the lack of data on the stress and motivation response in master athletes during competitions, as athletic performance in this age group can be significantly impacted by stress rather than appropriate training.

Methods: Coastal rowing beach sprint master athletes aged 43-57 years were examined to assess the saliva levels of stress biomarkers, cortisol, and testosterone. Specifically, samples were collected at awakening and before and after the boat race.

Adverse Reactions to the Orphan Drug Cerliponase Alfa in the Treatment of Neurolipofuscinosis Type 2 (CLN2).

Neuronal Ceroid Lipofuscinosis type 2 is a rare pathology affecting mainly the central nervous system (CNS) and retina, and is caused by variants in the gene encoding the lysosomal enzyme tripeptidyl peptidase 1. Therapy with enzyme replacement through the brain infusion of the orphan drug cerliponase alfa, a recombinant human tripeptidyl peptidase 1 enzyme replacement therapy delivered via intracerebroventricular infusion, has been approved for Neuronal Ceroid Lipofuscinosis type 2 disease. The safety profile of cerliponase alfa has been established based on pre-authorization studies; currently, no post-marketing investigation has been performed to confirm it.

Classification of Physical Activity Programs Based on the Kellgren & Lawrence Scale for Knee Osteoarthritis: A Systematic Review.

Introduction: Knee osteoarthritis is a common orthopaedic disease, is the leading cause of disability in the elderly, and can lead to pain, loss of function, and reduced quality of life. This research aims to determine how PA programs can be effectively classified and customised to align with the stages of knee OA according to the KL classification.

Objective: The research aims to fill the gap in understanding the relationship between the type and intensity of PA and the stages of OA as defined by the KL classification.

A case report on dietary needs of the rowing athlete winner of the triple crown.

Sports nutrition is a topic that is often misinterpreted and sometimes abused. The often-used "shot-gun" method to meeting caloric needs by simply increasing caloric intake disregarding nutrient source is scientifically contrary to the need for a more careful study of the nutritional requirements of rowers. Rowing by itself is a very demanding sport as typical training sessions use exercise intensities that range from very low submaximal work to short term supramaximal efforts.

Adverse Reactions to Evolocumab: Analysis of Real-World Data from EudraVigilance.

Background: Evolocumab is a humanized immunoglobulin G2 monoclonal antibody, directed against Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9), prescribed in hypercholesterolemic patients. The safety profile of this drug is currently defined by the data of pre-authorization clinical trials. The purpose of this study is to update knowledge of the safety of evolocumab through an analysis of post-marketing real-world data on suspected adverse reactions (SARs), reported by the EudraVigilance database system.