Publications by authors named "C Manna"
Mercury (Hg) is a highly toxic environmental contaminant that can harm human health, ultimately leading to endothelial dysfunction. Hg toxicity is partially mediated by the exposure of the cell membrane's surface of erythrocytes (RBCs) to phosphatidylserine (PS). In the context of these challenges, hydroxytyrosol, a phenolic compound of olive oil, has the ability to mitigate the toxic effects of Hg.
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- The StAR protein plays a crucial role in the initial steps of neuro/steroid production, which is important for hormone balance especially as we age.
- Aging leads to changes in the immune system and decreases in neurosteroids, increasing the risk of Alzheimer's disease (AD), particularly in women.
- Research shows that alterations in StAR levels and neurosteroid production are linked to AD pathology, highlighting the potential for retinoid signaling as a therapeutic target for improving brain health and reducing dementia risk.
In several physiopathological processes, phosphatidylserine (PS), normally sequestered to the inner leaflet of the plasma membrane, becomes exposed to the cell surface. In erythrocytes (RBC), PS externalization is a crucial event for the removal of aged/damaged cells but can also be associated with increased prothrombotic activity. Structurally related olive oil antioxidants, including hydroxytyrosol (HT), are able to significantly reduce the percentage of PS-exposing RBC, when cells are exposed to toxic compounds such as the heavy metal mercury (Hg).
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- In vitro fertilisation (IVF) is a popular way to help people who can't have babies, but it doesn't always work very well.
- Scientists are looking into how Artificial Intelligence (AI) can make IVF better by checking the quality of eggs (oocytes) since this affects embryo quality.
- There are still challenges to using AI in hospitals, like needing better data and ways to study eggs and embryos to improve success rates in having babies.
Male infertility represents a complex clinical condition that often challenges the ability of reproductive specialists to find its etiology and then propose an adequate treatment. The unexplained decline in sperm count, as well as the association between male infertility and mortality, morbidity, and cancer, has prompted researchers toward an urgent need to better understand the causes of male infertility. Therefore, molecular biologists are increasingly trying to study whether sperm epigenetic alterations may be involved in male infertility and embryo developmental abnormalities.
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