Concentration of cefuroxime in the bones of albino white rats: a comparative study of femur, humerus, and mandible.

The levels of cefuroxime in rat bones with a different morphology, function, blood supply, and proportion between lamellar and cancellous bone were studied, after a 24-h administration of 750mg/kg X 3. The concentrations in the right and left femora, humeri, and mandibles of the same animal were measured 2 h after the last administration. The result indicate statistically significant differences between femur and humerus (P less than 0.