Publications by authors named "C Manabe"
Taurine is a sulfur-containing amino acid derivative that can be found in the majority of mammalian tissues. Taurine is also present in the skin and is involved in maintaining skin homeostasis by exerting osmoregulatory and antioxidant effects. Previous studies have indicated that taurine treatment is effective against age-, ultraviolet- or detergent-induced skin dysfunction.
View Article and Find Full Text PDFProtective effect of taurine on UVB-induced skin aging in hairless mice.
Biomed Pharmacother
September 2021
Taurine, a sulfur-containing amino acid derivative, exists at a high concentration in the skin and is considered to play an important role in maintaining moisture homeostasis. This study investigated the effects of oral taurine supplementation on epidermal moisture content and wrinkle formation, as well as skin taurine content, using ultraviolet B (UVB)-irradiated hairless mice. Wrinkles were induced by exposing hairless mice to UVB radiation (70-100 mJ/cm).
View Article and Find Full Text PDFBackground: Xenotransplantation is an appealing alternative to human allotransplantation because of a worldwide shortage of organs. One of the obstacles for xenografts is cellular rejection by the innate immune system, comprised of NK cells, monocytes, and macrophages. In this study the inhibitory function of HLA-G1, a MHC Ib molecule, on macrophage-mediated cytotoxicity was examined.
View Article and Find Full Text PDFArticle Synopsis
- Melanoma tumor growth relies heavily on blood supply, which is supported by a process called angiogenesis.
- Local treatment with Sp1 decoy oligodeoxynucleotides (ODNs) significantly increased tumor necrosis and reduced blood vessel density in melanoma tumors, indicating an anti-angiogenic effect.
- The study found that this treatment decreased levels of important angiogenesis-related proteins, suggesting that Sp1 decoy ODNs could be a promising approach for fighting melanoma by inhibiting blood vessel formation.