Publications by authors named "C Malizia"
Purpose: This systematic review aimed to assess the feasibility, safety, and efficacy of using modern external beam radiotherapy (EBRT) techniques, such as intensity-modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT), and stereotactic body radiotherapy (SBRT) as alternative approaches to brachytherapy (BRT) in adjuvant treatment of endometrial cancer (EC).
Material And Methods: A systematic review was conducted following PRISMA guidelines. The research question was framed using the PICO method, focusing on patients with EC [P] and comparing modern EBRT techniques (IMRT, VMAT, SBRT) [I] vs.
Introduction: Biliary tract cancers (BTC) are rare and aggressive neoplasms. The current management of locally advanced or unresectable BTC is primarily based on chemotherapy (CHT) alone, linked to a median overall survival (OS) of approximately 12 months. However, international guidelines still consider concurrent chemoradiation (CRT) as an alternative treatment option.
View Article and Find Full Text PDFBackground/objectives: To evaluate T&N-staging diagnostic performance of [68Ga]Ga-FAPI-46 PET/CT (FAPI) in a suspected/confirmed lung cancer surgical cohort.
Methods: Patients were enrolled in a prospective monocentric trial (EudraCT: 2021-006570-23) to perform FAPI, in addition to conventional-staging-flow-chart (including [18F]F-FDG PET/CT-FDG). For the current purpose, only surgical patients were included.
Article Synopsis
- The study evaluates the effectiveness of the Q.Clear algorithm, specifically the β-level settings, for enhancing image quality in PET/CT scans for patients with neuroendocrine tumors.* -
- Compared to standard reconstruction, the β1600 setting showed superior performance in overall image quality and in detecting small lesions (less than 1 cm).* -
- Results indicated that patients with positive PET findings in discordant lesions were confirmed malignant, highlighting the importance of using β1600 reconstruction for accurate diagnosis.*
Article Synopsis
- The study focuses on identifying effective treatment responses in patients with metastatic castration-resistant prostate cancer (mCRPC) using positron emission tomography (PET) with different radiotracers.
- A total of 49 patients were randomly assigned to receive scans using C-Choline, F-FACBC, or Ga-PSMA before treatment and again 2 months later to evaluate their biochemical response, primarily looking for a PSA reduction of ≥50%.
- Results indicated that variations in metabolic tumor volume (MTV) and total lesion activity (TLA) with Ga-PSMA PET were significantly associated with treatment responses and could also predict progression-free survival and overall survival in patients.