Publications by authors named "C Maldonado"
Purpose/background: Clozapine is the recommended drug for treatment-resistant schizophrenia. Drug response could be affected by numerous factors such as age, sex, body mass index, co-medication, consumption of xanthine-containing beverages, smoking, and genetic variants of the enzymes involved in clozapine metabolism (CYP1A2, CYP3A4, and, to a lesser extent, CYP2C19 and CYP2D6). This study evaluated genetic and nongenetic variables that may affect clozapine plasma concentrations in Uruguayan patients with schizophrenia.
View Article and Find Full Text PDFStrategic interventions in clinical randomized trials for metabolic dysfunction-associated steatotic liver disease (MASLD) and obesity in the pediatric population: a systematic review with meta-analysis and bibliometric analysis.
BMC Med
November 2024
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), is a prevalent hepatic condition linked to metabolic alterations. It gradually causes liver damage and potentially progresses to cirrhosis. Despite its significance, research, especially in the pediatric population, is limited, leading to contradictory findings in diagnosis and treatment.
View Article and Find Full Text PDFThe rise of antibiotic-resistant bacteria in clinical settings has become a significant global concern. Among these bacteria, stands out due to its remarkable ability to acquire resistance genes and persist in hospital environments, leading to some of the most challenging infections. Horizontal gene transfer (HGT) plays a crucial role in the evolution of this pathogen.
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- A study investigated the relationship between COVID-19 vaccination and the risk of developing venous thrombosis or embolism (VTE) after infection, particularly examining the impact of booster shots.
- The research analyzed data from Military Health System beneficiaries who tested positive for COVID-19 between 2020 and 2022, finding that vaccinated individuals had significantly lower odds of developing VTE compared to those unvaccinated.
- Results indicated that the risk of post-COVID-19 VTE was particularly low during the Omicron variant era, and those receiving booster shots had an even greater reduction in VTE risk.
Article Synopsis
- The study explores how dyslipidemia, specifically oxidized LDL (OxLDL), affects the proliferation of prostatic stromal cells and the release of extracellular vesicles (EVs), which are linked to Benign Prostatic Hyperplasia (BPH).
- Mice were given a high-fat diet and human prostatic stromal cells were exposed to OxLDL, revealing that dyslipidemic conditions promote increased cell growth and the secretion of EVs that further stimulate this growth.
- Treatment with metformin was found to significantly reduce OxLDL-induced cell proliferation, suggesting it could be a potential therapeutic option for managing BPH by targeting the underlying mechanisms associated with dyslipidemia.