Publications by authors named "C Maignien"
Study Question: Is there an association between dydrogesterone exposure during early pregnancy and the reporting of birth defects?
Summary Answer: This observational analysis based on global safety data showed an increased reporting of birth defects, mainly hypospadias and congenital heart defects (CHD), in pregnancies exposed to dydrogesterone, especially when comparing to progesterone.
What Is Known Already: Intravaginal administration of progesterone is the standard of care to overcome luteal phase progesterone deficiency induced by ovarian stimulation in ART. In recent years, randomized controlled clinical trials demonstrated that oral dydrogesterone was non-inferior for pregnancy rate at 12 weeks of gestation and could be an alternative to micronized vaginal progesterone.
Study Question: What is the distribution of endometriosis phenotypes according to age in adult women undergoing surgery?
Summary Answer: The phenotype of endometriosis did not significantly vary after 24 years old.
What Is Known Already: The phenotypic evolution of endometriosis over time remains unclear. While adolescents can exhibit any type of endometriosis lesions, ovarian endometriosis (OMA) and/or deep-infiltrating endometriosis (DIE) tend to increase with age in young adults.
Objective: To provide evidence regarding the significance of painful symptoms among women suffering from infertility.
Design: An observational retrospective cross-sectional study.
Settings: University hospital-based research center.
Study Question: Do adolescents and young adult women (YAW) with histologically proven endometriosis present a specific clinical history?
Summary Answer: Questionnaire screening of adolescents and YAW can identify clinical markers associated with histologically proven endometriosis.
What Is Known Already: Some validated questionaries can contribute to an earlier endometriosis diagnosis in adults. None of these scores, however, have been validated for adolescents or YAW.