Experimental sensitization to subtilisin. I. Production of immediate- and late-onset pulmonary reactions.

Four experiments were undertaken to explore the nature of pulmonary sensitivity which may result from inhalation of subtilisin aerosols. In the first study, immediate- and late-onset responses were identified. Groups of guinea pigs were exposed to atmospheres containing 0.

Immunotoxicologic evaluation of the respiratory system: animal models for immediate- and delayed-onset pulmonary hypersensitivity.

A wide variety of industrial materials is known to cause allergic pulmonary reactions. Respiratory symptoms may occur either immediately upon exposure to the agent (immediate-onset response), or several hours later (delayed-onset reaction). In order to determine both the mechanism of response, and a safe exposure level which would prevent development of pulmonary sensitization, animal models are currently being developed for both types of sensitivity responses.