Publications by authors named "C Maftei"
Article Synopsis
- A 2.5-month-old girl was diagnosed with methylmalonic acidemia (MMA) due to a deficiency in transcobalamin II, affecting vitamin B12 metabolism, which resulted in failure to thrive and severe low blood cell counts (pancytopenia).
- She developed opportunistic Cytomegalovirus infections and pneumonia, leading to severe respiratory distress syndrome (ARDS) and immune reconstitution inflammatory syndrome (IRIS) after starting vitamin B12 treatment.
- In treating children with lung-related ARDS, doctors should not wait for normal lymphocyte counts to perform necessary invasive procedures for identifying infections, and quick high-dose corticosteroid treatment is crucial for managing inflammation linked to IRIS.
Article Synopsis
- - The study aimed to evaluate the effectiveness of combining comparative genomic hybridization and single-nucleotide polymorphism (CGH/SNP) analyses for risk stratification in pediatric acute lymphoblastic leukemia (ALL) compared to traditional cytogenetic methods.
- - Researchers analyzed data from 135 patients aged 1-18 diagnosed with ALL, finding that CGH/SNP had a significantly lower failure rate and faster result turnaround (5.8 days) than conventional karyotyping (10.7 days).
- - CGH/SNP detected crucial gene deletions, particularly ETV6, which was associated with better event-free survival, indicating that CGH/SNP could enhance diagnostic accuracy and prognostic evaluation in pediatric ALL.
Air pollution poses one of the greatest dangers to public well-being. This article outlines a study conducted in the Central Romania Region regarding the health risks associated with particulate matter (PM) of two sizes, viz., PM and PM.
View Article and Find Full Text PDFThere are more than 900 genetic syndromes associated with oral manifestations. These syndromes can have serious health implications, and left undiagnosed, can hamper treatment and prognosis later in life. About 6.
View Article and Find Full Text PDFArticle Synopsis
- The study introduces two new alkaloids, 6'-Amino-cinchonine and 6'-Amino-cinchonidine, which feature a primary amino group in their structure, potentially enabling new chemical applications.
- A method for synthesizing triazole derivatives from these compounds is outlined using the [3 + 2] Huisgen cycloaddition, involving the conversion of amines to azides.
- The synthesis includes non-substituted and silyl-protected triazoles, with some derivatives analyzed via X-ray diffraction to explore the structural relationship between the quinuclidine ring and the triazole.