Publications by authors named "C MacNeil"
Highly fragmented ribosomal RNA-coding sequences are characteristic of mitogenomes of protozoan parasites of the phylum Apicomplexa. Identification of ribosomal RNA encoding sequences in apicomplexan mitogenomes has largely relied on sequence similarity with several apicomplexan species for which expression of these genes has been demonstrated. The present study applied Next-Gen sequencing to investigate the expression of fragmented putative mitochondrial rRNAs inEimeria tenella, a coccidian parasite of poultry.
View Article and Find Full Text PDFObjectives: Early maladaptive schemas represent unhelpful frameworks of cognitions, emotions and subsequent behavioural responses and can be associated with depressive symptoms. Caregivers of individuals with serious mental illness (SMI) frequently report experiencing depressive symptoms. It is unclear whether depressive symptoms in caregivers are influenced by schemas.
View Article and Find Full Text PDFArticle Synopsis
- The text discusses a method for catalyzing asymmetric hydrogenation of indazole-containing enamides, specifically for synthesizing zavegepant, a new migraine treatment.
- It highlights the effectiveness of both neutral bis(phosphine)cobalt(II) and cationic bis(phosphine)cobalt(I) complexes as precatalysts, achieving high yields and selectivity in the hydrogenation reactions.
- Additionally, it mentions the successful hydrogenation of a specific enamide on a large scale (20 grams), showing practical application in the synthesis process.
Increased cortical surface area but not altered cortical thickness or gyrification in bipolar disorder following stabilisation from a first episode of mania.
Prog Neuropsychopharmacol Biol Psychiatry
March 2023
Background: Despite reports of altered brain morphology in established bipolar disorder (BD), there is limited understanding of when these morphological abnormalities emerge. Assessment of patients during the early course of illness can help to address this gap, but few studies have examined surface-based brain morphology in patients at this illness stage.
Methods: We completed a secondary analysis of baseline data from a randomised control trial of BD individuals stabilised after their first episode of mania (FEM).