DigiLoCS: A leap forward in predictive organ-on-chip simulations.

Digital twins, driven by data and mathematical modelling, have emerged as powerful tools for simulating complex biological systems. In this work, we focus on modelling the clearance on a liver-on-chip as a digital twin that closely mimics the clearance functionality of the human liver. Our approach involves the creation of a compartmental physiological model of the liver using ordinary differential equations (ODEs) to estimate pharmacokinetic (PK) parameters related to on-chip liver clearance.

Electrotaxis of Self-Propelling Artificial Swimmers in Microchannels.

Biological microswimmers alter their swimming trajectories to follow the direction of an applied electric field, exhibiting electrotaxis. We show that synthetic active droplet microswimmers also autonomously change swimming trajectories in microchannels, even undergoing "U-turns," in response to an electric field, mimicking electrotaxis. We exploit such electrotaxis, in the presence of an external flow, to robustly tune the swimming trajectory of active droplets between wall-adjacent, oscillatory, and channel centerline swimming.

Unique Metabolomic and Lipidomic Profile in Serum From Patients With Crohn's Disease and Ulcerative Colitis Compared With Healthy Control Individuals.

Background: Accurate biomarkers for disease activity and progression in patients with inflammatory bowel disease (IBD) are a prerequisite for individual disease characterization and personalized therapy. We show that metabolic profiling of serum from IBD patients is a promising approach to establish biomarkers. The aim of this work was to characterize metabolomic and lipidomic serum profiles of IBD patients in order to identify metabolic fingerprints unique to the disease.

Hydrogen online monitoring based on thermal conductivity for anaerobic microorganisms.

H -producing microorganisms are a promising source of sustainable biohydrogen. However, most H -producing microorganisms are anaerobes, which are difficult to cultivate and characterize. While several methods for measuring H exist, common H sensors often require oxygen, making them unsuitable for anaerobic processes.

Hydrodynamic interactions between squirmers near walls: far-field dynamics and near-field cluster stability.

Confinement increases contacts between microswimmers in dilute suspensions and affects their interactions. In particular, boundaries have been shown experimentally to lead to the formation of clusters that would not occur in bulk fluids. To what extent does hydrodynamics govern these boundary-driven encounters between microswimmers? We consider theoretically the symmetric boundary-mediated encounters of model microswimmers under gravity through far-field interaction of a pair of weak squirmers, as well as the lubrication interactions occurring after contact between two or more squirmers.