Publications by authors named "C M Yea"
Long-term prophylaxis (LTP) has been shown to reduce the frequency of hereditary angioedema (HAE) attacks; however, attacks occurring in patients receiving LTP have not been well characterized. The objective of this systematic review was to evaluate the proportion of type I/II HAE (HAE-C1INH) patients who experience attacks while receiving LTP, the characteristics of these attacks, and associated on-demand therapy use. A systematic search was conducted in PubMed to identify studies reporting LTP use with plasma-derived C1 inhibitor (pdC1INH), lanadelumab, berotralstat, androgens, or antifibrinolytics in patients with HAE-C1INH.
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- * Results showed that both doses of sebetralstat provided significantly quicker relief from symptoms and attack severity compared to the placebo, with median times to relief around 1.6-1.8 hours versus over 6 hours for placebo.
- * The trial included 136 participants who treated 264 attacks, demonstrating that sebetralstat could potentially offer a more convenient oral alternative to current parenteral treatments for hereditary angioedema.
Introduction: Little is known about the longitudinal trajectory of brain growth in children with opsoclonus-myoclonus ataxia syndrome. We performed a longitudinal evaluation of brain volumes in pediatric opsoclonus-myoclonus ataxia syndrome patients compared with age- and sex-matched healthy children.
Patients And Methods: This longitudinal case-control study included brain magnetic resonance imaging (MRI) scans from consecutive pediatric opsoclonus-myoclonus ataxia syndrome patients (2009-2020) and age- and sex-matched healthy control children.
Clinical features and outcomes in children with seronegative autoimmune encephalitis.
Dev Med Child Neurol
October 2024
Aim: To characterize the presenting features and outcomes in children with seronegative autoimmune encephalitis, and to evaluate whether scores at nadir for the Modified Rankin Scale (mRS) and Clinical Assessment Scale for Autoimmune Encephalitis (CASE) or its paediatric-specific modification (ped-CASE) are predictive of outcomes.
Method: This observational study included children younger than 18 years of age with seronegative autoimmune encephalitis. Demographics and clinical data were collected.
Article Synopsis
- Epstein-Barr virus (EBV) seropositivity rates in children with multiple sclerosis (MS) are notably lower compared to adults, raising questions about EBV's necessity in MS development.
- A study analyzed 251 children with demyelination and found that when accounting for MOGAD (myelin oligodendrocyte glycoprotein-associated disease), over 90% of MS children had evidence of EBV infection.
- The results support EBV's significant role in the MS spectrum while highlighting different biological mechanisms between MS and MOGAD.