Publications by authors named "C M Villalon"
Article Synopsis
- Migraine is a complicated disorder, with calcitonin gene-related peptide (CGRP) playing a key role in its understanding and the development of new treatments like gepants and monoclonal antibodies, which are effective and safe for patients.
- A narrative review investigated CGRP's role in migraines and analyzed the effects of CGRP-targeted medications regarding how they work and how the body processes them.
- While current CGRP medications show effectiveness, they have limitations, like side effects and varying efficacy among patients; some patients' migraines may persist due to the complexity of migraine mechanisms and medication properties.
Glyphosate, a widely used herbicide, is linked to a plethora of deleterious effects in both clinical and preclinical studies. Nevertheless, the effects of its main metabolite, aminomethylphosphonic acid (AMPA), whose half-life in soil is even longer than that of glyphosate, have been little explored. On this basis, as a first approach, in this work, we report that intraperitoneal (i.
View Article and Find Full Text PDFTransient receptor potential (TRP) channels are pivotal in modulating vascular functions. In fact, topical application of cinnamaldehyde or capsaicin (TRPA1 and TRPV1 channel agonists, respectively) induces "local" changes in blood flow by releasing vasodilator neuropeptides. We investigated TRP channels' contributions and the pharmacological mechanisms driving vasodilation in human isolated dermal arteries.
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- Purine nucleosides and nucleotides like ATP can affect cardiovascular responses, with adenosine-5'-(β-thio)-diphosphate (ADPβS) causing vasodilatation through purinergic P2Y receptors.
- A study tested the specific P2Y receptor subtypes involved in blood pressure changes induced by ADPβS in male Wistar rats, using various antagonists and different experimental conditions.
- Findings showed that initial decreases in diastolic blood pressure from ADPβS were linked to peripheral P2Y receptor activation, while later increases in systolic blood pressure also implicated multiple P2Y receptor types.