Publications by authors named "C M T Dvorak"
Article Synopsis
- - C1q deficiency is a rare immune disorder that increases the risk of infections and autoimmune diseases similar to systemic lupus erythematosus (SLE), often leading to various health complications.
- - An international study involving 18 patients evaluated the outcomes of hematopoietic stem cell transplantation (HSCT) for C1q deficiency, showing a 71% overall survival rate and improvement in autoimmune symptoms for most patients.
- - The study highlights that patients with severe autoimmune symptoms have poorer survival rates, and specific antibodies were linked to different organ involvements, emphasizing the need for careful patient selection and risk assessment for HSCT as a treatment option.
Article Synopsis
- Diffuse alveolar hemorrhage (DAH) is a serious lung complication that can occur after hematopoietic cell transplantation (HCT) in patients under 21, with a low incidence rate of about 1% in this population.
- A study analyzed data from nearly 7,000 patients to identify risk factors for developing DAH, finding that nonmalignant hematologic disease, specific transplant medication regimens, and severe acute graft-versus-host disease significantly increased the risk.
- Critical care patients with DAH also showed higher instances of various health issues, including systemic and pulmonary hypertension, and other serious conditions like renal failure.
Article Synopsis
- * Researchers analyzed 562 patients across four IEI subgroups (combined immunodeficiency, severe combined immunodeficiency, neutrophil disorders, and hemophagocytic lymphohistiocytosis-related disorders), focusing on event-free survival (EFS) as the main outcome.
- * The study concluded that targeting a cumulative busulfan exposure (AUCNONMEM) of around 80 mg × h/L can improve EFS and donor chimer
We hypothesized that the inferior disease-free survival (DFS) seen in older patients who underwent αβ-T-cell/CD19-depleted (AB-TCD) haploidentical hematopoietic cell transplantation (HCT) for hematologic malignancies is caused by excessive exposure to rabbit antithymocyte globulin (rATG; Thymoglobulin). Between 2015 and 2023, 163 patients with a median age of 13 years (range, 0.4-27.
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